ConductScreen
From Analysis to Adoption

Culture Chip

A standardized microfluidic culture device for neural organoid developmental neurotoxicity screening — built on ConductScience's existing commercial microfluidic product line.

From stem cell to safety assessment — in any laboratory. Preliminary design complete; a product-line adaptation of existing microfluidic manufacturing, with Phase 3 fabrication and validation planned.

The Problem

Only ~120 compounds have ever been tested for developmental neurotoxicity under OECD TG 426. Each study costs $1-2M, takes 6+ months, and uses rodents with fundamentally different brain development from humans.

The Solution

A complete testing system that any lab can use. Human-relevant iPSC-derived organoids, standardized culture on a microfluidic chip, automated image analysis, and regulatory-grade reporting — all integrated.

Existing Capability

Built on Proven Manufacturing

ConductScience already manufactures and distributes custom microfluidic chips for life science applications (3D Cell Culture Chip, Observation Chip, PDMS Kit). Culture Chip is a product-line adaptation, not a greenfield hardware project.

Glass, PMMA, Thermoplastic

Multiple substrate materials for application-specific optimization

Microfluidic Devices

Current product line includes chips for cell culture and drug screening

Custom Design

Application-specific chip design and mold tooling for specialized workflows

Global Distribution

Established supply chain serving thousands of research labs worldwide

Learn more about ConductScience's microfluidic chip capabilities: Custom Microfluidic Chips · Purchasing Guide

Integrated System

Four components work together to deliver a complete developmental neurotoxicity assessment from a single brightfield image.

Hardware

Culture Chip

Microfluidic culture device

Protocol

Standard Protocol

Seed, differentiate, dose, image

Existing Equipment

Any Microscope

Standard inverted brightfield

Software

ConductScreen

Automated analysis + report

Chip Design

Microscope-slide format microfluidic device with 4 wells, perfusion channels, dosing ports, and an optical-grade bottom.

Culture Chip (25 mm x 75 mm)Well 1Well 2Well 3Well 4MediaWasteOptical-grade bottom for brightfield imagingDrug dosing ports~ 50 mm

System Components

Workflow Comparison

Current: OECD TG 426 (Animal)
  1. 1Procure animals
  2. 2House + breed colony
  3. 3Dose pregnant dams daily
  4. 4Wait for birth + litter culling
  5. 5Behavioral testing battery
  6. 6Sacrifice + perfusion fixation
  7. 7Brain sectioning + staining
  8. 8Histopathology + manual scoring

6-12

months

$1-2M

per compound

500+

animals

Culture Chip Workflow
  1. 1Seed iPSCs on Culture Chip
  2. 2Follow standard protocol (45 days)
  3. 3Add substance at defined doses
  4. 4Image on any inverted microscope
  5. 5Upload to ConductScreen
  6. 6Automated multi-modal assessment
  7. 7Regulatory-grade report generated
  8. 8Results in hours, not months

2-3

months

$5-15K

per compound

0

animals

Adoption Model

Everything you need to run developmental neurotoxicity screening — and nothing you don't.

ComponentWhat You GetPricing
Culture ChipDisposable 4-8 well microfluidic devicePer chip
Media KitPre-mixed differentiation + exposure reagentsPer kit
ConductScreenAnalysis platform + regulatory reportsAnnual subscription
Protocol + TrainingFull documentation + onboardingIncluded

What Your Lab Needs

Standard inverted brightfield microscope
CO2 incubator (standard cell culture)
Biosafety cabinet (standard cell culture)
Organoid expertise(NOT required)
Fluorescence microscope(NOT required)
Custom analysis software(NOT required)
Animal facility(NOT required)

Development Timeline

Phase 2 (2026-27)

NAM Validation

  • Software validated with conventional culture
  • Ethanol + VPA dose-response curves
  • 2 independent labs confirmed
  • NDHCC + VQN engagement initiated
  • Performance standards defined
Phase 3 (2027-28)

Culture Chip Integration

  • Culture Chip prototype fabricated
  • Head-to-head validation vs conventional culture
  • Multi-substance, multi-lab study
  • VQN prototype delivered to NDHCC
  • OECD alignment initiated

Why ConductScience

ConductScience already manufactures custom microfluidic chips for cell culture, observation, and drug screening applications. Culture Chip is a product-line adaptation — not a new venture.

10+

Years manufacturing scientific equipment

1000+

Active research lab customers worldwide

Microfluidics

Current microfluidic chip manufacturing

Full Stack

Hardware + software + data integration

Interested in Early Access?

Culture Chip is currently in specification phase, building on ConductScience's existing microfluidic chip manufacturing platform. Contact us for collaboration or early access.